Multiple Sclerosis After Infectious Mononucleosis

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Multiple sclerosis after infectious mononucleosis.

BACKGROUND Infectious mononucleosis caused by the Epstein-Barr virus has been associated with increased risk of multiple sclerosis. However, little is known about the characteristics of this association. OBJECTIVE To assess the significance of sex, age at and time since infectious mononucleosis, and attained age to the risk of developing multiple sclerosis after infectious mononucleosis. DE...

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Multiple sclerosis after infectious mononucleosis: record linkage study.

OBJECTIVE To ascertain if infectious mononucleosis is a risk factor for the development of multiple sclerosis (MS); and, if it is, whether its effect is close to or remote in time from the onset of MS. DESIGN Analysis of database of linked abstracts of records of hospital admission and death. SETTING Health region in central southern England. MAIN OUTCOME MEASURE Ratio of rate of MS in a ...

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Infectious mononucleosis and risk for multiple sclerosis: a meta-analysis.

OBJECTIVE To characterize the association between infectious mononucleosis (IM), a frequent clinical manifestation of primary Epstein-Barr virus infection after childhood, and the risk for multiple sclerosis (MS). METHODS We conducted a systematic review and meta-analysis of case-control and cohort studies of IM and MS. RESULTS The combined relative risk of MS after IM from 14 studies was 2...

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Selective association of multiple sclerosis with infectious mononucleosis.

Previous studies have suggested an association between multiple sclerosis (MS) and infectious mononucleosis (IM) but data on the exact strength of this association or its selectivity have been conflicting. In this study we have evaluated the association between MS and a variety of common childhood infections and afflictions in a large population-based case-control study involving 2,877 MS cases...

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Obesity interacts with infectious mononucleosis in risk of multiple sclerosis

BACKGROUND AND PURPOSE The possible interaction between adolescent obesity and past infectious mononucleosis (IM) was investigated with regard to multiple sclerosis (MS) risk. METHODS This report is based on two population-based case-control studies, one with incident cases (1780 cases, 3885 controls) and one with prevalent cases (4502 cases, 4039 controls). Subjects were categorized based on...

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ژورنال

عنوان ژورنال: Archives of Neurology

سال: 2007

ISSN: 0003-9942

DOI: 10.1001/archneur.64.1.72